Work Team
- Autor
- INER
- Fecha de publicación
- 08 de agosto de 2017
- Fecha de actualización
- 22 de abril de 2021
Blanca Bazán-Perkins, MSc PhD
Head of Immunopharmacology Lab
E-mail.perkins@unam.mx, perkins@iner.gob.mx
Personal Websites:
https://orcid.org/0000-0003-1331-6349
https://publons.com/researcher/441820/blanca-bazan-perkins/
Our research group has focused on the development of experimental models for the study of cellular, molecular, immunometabolic and pharmacological aspects of various respiratory diseases in order to carry out traslational medicine. Experimental models have allowed us to identify the pathophysiological features of various phenotypes of allergic asthma, the progression of the disease, as well as other allergic and non-allergic pathologies of the respiratory system.
Areas of interest:
Study of the mechanisms of cellular signaling from the proteomic analysis of the smooth muscle of the airways.
Evaluation of drugs designed for the control of inflammation and allergic response in respiratory diseases.
Biomarkers for the detection and clinical assessment of some respiratory diseases.
Karen Bobadilla Lozoya MD, PhD
Areas of interest:
We are interested in the study of the immune response against intracellular pathogens affecting the respiratory tract in an in vitro hyperglycemia model. Specifically, we focus on the processing and presentation of Mycobacterium tuberculosis (Mtb) antigens in macrophages (M1 and M2) and dendritic cells in an in vitro model of hyperglycemia in order to elucidate the mechanisms that are affected by high glucose concentrations. In this sense, the objectives are: 1) To study proteins involved in Mtb processing in the in vitro hyperglycemia model. 2) To study presentation of Mtb in the context of class II molecules in the in vitro hyperglycemia model. 3) To study intravesicular trafficking as well as vesicular interactions in the in vitro hyperglycemia model.
Angélica Flores Flores, PhD
Researcher in Medical Sciences C
SNI level 1
E-mail. angelica.flores@iner.gob.mx; ffa_ff@uaem.mx
Personal Websites:
https://www.researchgate.net/profile/Angelica_Flores_Flores
https://orcid.org/0000-0002-3431-3879
Pharmacology has played an important role in the development of drugs for effective and safe therapies against noncommunicable diseases; But so far it remains a challenge. Therefore, in this working group there is an interest in the search for bioactive compounds of natural, synthetic and semi-synthetic origin to find leading compounds that are subjected to preclinical toxicity tests, in vitro effect, ex vivo and in vivo, as well as pharmacokinetic studies, with which we can know its pharmacological safety, novel mechanisms of action and behavior in the temporal course within the body for the treatment of respiratory diseases such as asthma and chronic degenerative diseases.
Currently, we find projects that are focused on the search for new bioactive molecules for the treatment of asthma and chronic degenerative diseases from natural, synthetic, semi-synthetic products and using new technologies for the generation of formulations focused on the respiratory tract .
Research lines:
Within their research lines that are located are:
1.- “Design, obtaining and evaluation of compounds of natural and synthetic origin for the treatment of asthma”
2.- “Preclinical studies of bioactive molecules for noncommunicable diseases”
3.- “Validation and pharmacokinetics of analytical methods for anti-asthmatic drugs”
4.- “Evaluation of new formulations with the use of nanotechnology in the treatment of respiratory diseases”
María Teresa Santos-Mendoza, PhD.
E-mail. tesalonster@gmail.com , tsantos@iner.gob.mx
https://www.researchgate.net/profile/Teresa_Santos-Mendoza
We are interested in the molecular mechanisms that govern the immune response to airways infectious diseases, and the potential mechanisms of such infectious agents to evade host immune response. We described for the first time the expression and regulation of PDZ polarity proteins in human antigen presenting cells (APCs), including monocytes, macrophages (M) and dendritic cells (DCs). Furthermore, we described that two PDZ proteins, Scrib and Dlg1, are required for DC maturation thus, for efficient T cell stimulation. Notably, some of these proteins can be targeted by the non-structural protein 1 (NS1) of the influenza A virus (IAV). In massive analyses of gene expression we have identified that more members of the PDZ family are expressed and regulated in APCs. These findings led us to propose that: 1) PDZ polarity proteins have important functions in APCs biology, and 2) The viral targeting of PDZ polarity proteins in DCs, and probably additional APCs, may constitute an immune evasion mechanism used by diverse pathogens including IAV and SARS-CoV-2. Combining diverse fields of knowledge including cell biology, molecular biology and immunology, as well as technical approaches such as confocal microscopy, proteomics and massive gene expression analyses among others, our investigation is focusing in: 1) The functions of diverse PDZ polarity proteins in APCs; 2) the regulation of immune response by viral proteins; and 3) the mechanisms used by viruses and probably other pathogens for immune evasion.
Recent publications:
1. Dante Barreda, Luis H. Gutiérrez-González, Erasmo Martínez-Cordero, Carlos Cabello-Gutiérrez, Rommel Chacón-Salinas and Teresa Santos-Mendoza. (2020). The Scribble Complex PDZ Proteins in Immune Cell Polarities. Journal of Immunology Research. 2020:5649790. doi: 10.1155/2020/5649790
2. Dante Barreda, Lucero A. Ramón-Luing, Olivia Duran-Luis, Karen Bobadilla, Rommel Chacón-Salinas and Teresa Santos-Mendoza. (2020). Scrib and Dlg1 polarity proteins regulate Ag presentation in human dendritic cells. Journal of Leukocyte Biology. 2020;108:883-893. DOI: 10.1002/JLB.4MA0320-544RR
3. Luis Horacio Gutiérrez-González and Teresa Santos-Mendoza. (2019). Viral targeting of PDZ polarity proteins in the immune system as a novel evasion mechanism. FASEB J. 33(10):10607-10617. doi: 10.1096/fj.201900518R. Epub 2019 Jul 23.
4. Dante Barreda, Marisa Sánchez-Galindo, Jessica López-Flores, Karen E. Nava-Castro, Karen Bobadilla, Alfonso Salgado-Aguayo and Teresa Santos-Mendoza. (2018). PDZ Proteins are Expressed and Regulated in Antigen-Presenting Cells and are Target of Influenza A Virus. Journal of Leukocyte Biology. 103 (4): 731-738. doi: 10.1002/JLB.4AB0517-184R.
Head of Immunopharmacology Lab
E-mail.perkins@unam.mx, perkins@iner.gob.mx
Personal Websites:
https://orcid.org/0000-0003-1331-6349
https://publons.com/researcher/441820/blanca-bazan-perkins/
Our research group has focused on the development of experimental models for the study of cellular, molecular, immunometabolic and pharmacological aspects of various respiratory diseases in order to carry out traslational medicine. Experimental models have allowed us to identify the pathophysiological features of various phenotypes of allergic asthma, the progression of the disease, as well as other allergic and non-allergic pathologies of the respiratory system.
Areas of interest:
Study of the mechanisms of cellular signaling from the proteomic analysis of the smooth muscle of the airways.
Evaluation of drugs designed for the control of inflammation and allergic response in respiratory diseases.
Biomarkers for the detection and clinical assessment of some respiratory diseases.
Karen Bobadilla Lozoya MD, PhD
Areas of interest:
We are interested in the study of the immune response against intracellular pathogens affecting the respiratory tract in an in vitro hyperglycemia model. Specifically, we focus on the processing and presentation of Mycobacterium tuberculosis (Mtb) antigens in macrophages (M1 and M2) and dendritic cells in an in vitro model of hyperglycemia in order to elucidate the mechanisms that are affected by high glucose concentrations. In this sense, the objectives are: 1) To study proteins involved in Mtb processing in the in vitro hyperglycemia model. 2) To study presentation of Mtb in the context of class II molecules in the in vitro hyperglycemia model. 3) To study intravesicular trafficking as well as vesicular interactions in the in vitro hyperglycemia model.
Angélica Flores Flores, PhD
Researcher in Medical Sciences C
SNI level 1
E-mail. angelica.flores@iner.gob.mx; ffa_ff@uaem.mx
Personal Websites:
https://www.researchgate.net/profile/Angelica_Flores_Flores
https://orcid.org/0000-0002-3431-3879
Pharmacology has played an important role in the development of drugs for effective and safe therapies against noncommunicable diseases; But so far it remains a challenge. Therefore, in this working group there is an interest in the search for bioactive compounds of natural, synthetic and semi-synthetic origin to find leading compounds that are subjected to preclinical toxicity tests, in vitro effect, ex vivo and in vivo, as well as pharmacokinetic studies, with which we can know its pharmacological safety, novel mechanisms of action and behavior in the temporal course within the body for the treatment of respiratory diseases such as asthma and chronic degenerative diseases.
Currently, we find projects that are focused on the search for new bioactive molecules for the treatment of asthma and chronic degenerative diseases from natural, synthetic, semi-synthetic products and using new technologies for the generation of formulations focused on the respiratory tract .
Research lines:
Within their research lines that are located are:
1.- “Design, obtaining and evaluation of compounds of natural and synthetic origin for the treatment of asthma”
2.- “Preclinical studies of bioactive molecules for noncommunicable diseases”
3.- “Validation and pharmacokinetics of analytical methods for anti-asthmatic drugs”
4.- “Evaluation of new formulations with the use of nanotechnology in the treatment of respiratory diseases”
María Teresa Santos-Mendoza, PhD.
E-mail. tesalonster@gmail.com , tsantos@iner.gob.mx
https://www.researchgate.net/profile/Teresa_Santos-Mendoza
We are interested in the molecular mechanisms that govern the immune response to airways infectious diseases, and the potential mechanisms of such infectious agents to evade host immune response. We described for the first time the expression and regulation of PDZ polarity proteins in human antigen presenting cells (APCs), including monocytes, macrophages (M) and dendritic cells (DCs). Furthermore, we described that two PDZ proteins, Scrib and Dlg1, are required for DC maturation thus, for efficient T cell stimulation. Notably, some of these proteins can be targeted by the non-structural protein 1 (NS1) of the influenza A virus (IAV). In massive analyses of gene expression we have identified that more members of the PDZ family are expressed and regulated in APCs. These findings led us to propose that: 1) PDZ polarity proteins have important functions in APCs biology, and 2) The viral targeting of PDZ polarity proteins in DCs, and probably additional APCs, may constitute an immune evasion mechanism used by diverse pathogens including IAV and SARS-CoV-2. Combining diverse fields of knowledge including cell biology, molecular biology and immunology, as well as technical approaches such as confocal microscopy, proteomics and massive gene expression analyses among others, our investigation is focusing in: 1) The functions of diverse PDZ polarity proteins in APCs; 2) the regulation of immune response by viral proteins; and 3) the mechanisms used by viruses and probably other pathogens for immune evasion.
Recent publications:
1. Dante Barreda, Luis H. Gutiérrez-González, Erasmo Martínez-Cordero, Carlos Cabello-Gutiérrez, Rommel Chacón-Salinas and Teresa Santos-Mendoza. (2020). The Scribble Complex PDZ Proteins in Immune Cell Polarities. Journal of Immunology Research. 2020:5649790. doi: 10.1155/2020/5649790
2. Dante Barreda, Lucero A. Ramón-Luing, Olivia Duran-Luis, Karen Bobadilla, Rommel Chacón-Salinas and Teresa Santos-Mendoza. (2020). Scrib and Dlg1 polarity proteins regulate Ag presentation in human dendritic cells. Journal of Leukocyte Biology. 2020;108:883-893. DOI: 10.1002/JLB.4MA0320-544RR
3. Luis Horacio Gutiérrez-González and Teresa Santos-Mendoza. (2019). Viral targeting of PDZ polarity proteins in the immune system as a novel evasion mechanism. FASEB J. 33(10):10607-10617. doi: 10.1096/fj.201900518R. Epub 2019 Jul 23.
4. Dante Barreda, Marisa Sánchez-Galindo, Jessica López-Flores, Karen E. Nava-Castro, Karen Bobadilla, Alfonso Salgado-Aguayo and Teresa Santos-Mendoza. (2018). PDZ Proteins are Expressed and Regulated in Antigen-Presenting Cells and are Target of Influenza A Virus. Journal of Leukocyte Biology. 103 (4): 731-738. doi: 10.1002/JLB.4AB0517-184R.
Imprime la página completa
La legalidad, veracidad y la calidad de la información es estricta responsabilidad de la dependencia, entidad o empresa productiva del Estado que la proporcionó en virtud de sus atribuciones y/o facultades normativas.